The A-list star, who is already known for her humanitarian work on various causes, wondered aloud whether she would better achieve her aims as an actress or in another role.
"When you work as a humanitarian, you are conscious that politics have to be considered," she told Vanity Fair in a cover story.
Checkout the cover:
Vanity Fair: Facebook
"Because if you really want to make an extreme change, then you have a responsibility," she added, before saying: "But I honestly don't know in what role I would be more useful - I am conscious of what I do for a living, and that (could) make it less possible."
Asked directly if she could pursue a life in politics, diplomacy or public service, she replied: "I am open." She gave no more details.
Since 2012 Jolie has travelled on more than 40 missions around the world as a special envoy for the United Nations Refugee Agency. Last year Jolie was awarded an honorary Oscar for her humanitarian work.
Check out this adorable pic of the actress with her then little son Maddox, posted on Vanity Fair's Facebook:
Jolie's directorial debut feature, 2011's Golden Globe-nominated In the Land of Blood and Honey, was set against the background of the early 1990s Bosnian war.
Her upcoming film, Unbroken, is about Olympian and World War II POW survivor Louis Zamperini. It will be released on December 25 in the United States.
Jolie will next direct a "sweeping epic" film about veteran Kenyan conservationist Richard Leakey's fight with ivory poachers, the studio behind the movie announced in September.