The "Nightly Show" host had some pointed words for Lemon, who became a target of some social media anger for opening his CNN
show by holding up a card with the N-word written on it and asking, "Does this offend you?"
Lemon's segment was in response to President Obama's use of the word in a podcast discussion on racism arising from last week's shooting of nine blacks in a Charleston, South Carolina, church.
"You want to see what really offends me?" Wilmore asked on his show Wednesday, picking up a card with the words "Don Lemon" printed on it.